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Is covid vaccine causing excess death globally?

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Excess deaths reflect the gap between the total number of deaths that occur for any reason and the amount that would be expected under normal circumstances.

Given the massive undercounting of the mortality toll both directly and indirectly attributed to COVID-19, excess mortality provides a useful way to get a glimpse of the true mortality toll.

Unfortunately, data on excess mortality are sparsely available: as of September 2021, only 84 countries release some sort of data (national or subnational; regular or one-off) on excess deaths.

Excess death estimates

This is where the excess deaths model of The Economist comes in. It represents a comprehensive attempt to fill the gaps with estimates based on the information that IS available: over 100 indicators that associate with and help predict excess deaths.

Below we show the mid-point estimates that derive from this model for the cumulative excess death rate: the total number of people who have died due to COVID-19 since the start of the pandemic normalized by population.  We show the results first by World Bank income classification and then by World Bank region.

The first set of results in the above chart are astonishing (they formed the basis of an earlier blog):

  • In contrast to popular perception, lower-middle-income countries, not high-income countries, have suffered the most mortality-wise.
  • Excess death rates of all other income groups seem to have converged to a roughly similar number.

The results by World Bank region are as follows:

  • Europe & Central Asia (ECA), Latin America and the Caribbean (LAC) and South Asia (SAR) experienced the highest cumulative excess death rates.
  • East Asia and the Pacific (EAP) registered the lowest values.
  • Interestingly, Sub-Saharan Africa (SSA) did worse than EAP according to the mid-point estimates. That’s despite SSA’s much-younger population structure.

Vaccine equity and excess deaths

The above estimates are presented as mid-points and considerable uncertainty surrounds them. Even so, if we can accept that they provide a roughly accurate approximation of the true order of magnitude of the suffering this health emergency has brought, then it is clear that the developing world has been severely hit – in fact, much more severely than what reported statistics would suggest.

Such conclusion also implies that the unequal distribution of vaccines is all the more untenable.

While not the simplest to interpret at first glance, the visualizations below capture that notion. They are based on the concept of revealed comparative advantage in trade, except that in this case we turn it around and depict the comparative disadvantage. Specifically, we show for each income group or region the share of that entity in the global total for excess deaths and vaccines. We then divide the excess death share by the vaccine share.

If vaccines were distributed somewhat in line with the likely suffering of countries, we would expect that these ratios equalize at roughly 1. In other words, the distribution of vaccines more or less matches that of excess deaths.

The chart above (which cuts the data by World Bank income classification) shows that the very different distributions of excess deaths and vaccines lead to a large inequality in the ratio across income groups:

  • Low-income countries have an excess death share that is many times the vaccine share.
  • For lower-middle-income countries, the ratio is much lower but still well above 1.
  • The ratio is similar for upper-middle-income countries (largely thanks to China) and high-income countries, where on average the vaccine share is ~double the excess death share.
  • Given the performance of UMICs (driven by China), the result for the developing world in the aggregate (which comprises UMICs, LMICs and LICs) is actually well balanced at around 1.

The results by World Bank region provide further granularity. SSA’s share in excess deaths is much higher than its share in global vaccines. We also see imbalances in other developing regions: SAR and MNA (Middle East and North Africa). EAP has an extremely low value which is the result from its generally low excess death rate and its overall stellar performance on the vaccination front. Other regions are in the middle.

The above results remind us that (1) the impact of the pandemic on the developing world has been far more severe than suggested by the officially reported data and (2) the inequity associated with the international distribution of vaccines turns out a lot worse once we take into account the joint distribution of excess deaths and vaccines.

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